Salinomycin - A New Cancer Drug Candidate

被引：88
|
作者：
Huczynski, Adam [1 ]
机构：
[1] Adam Mickiewicz Univ, Fac Chem, Dept Biochem, PL-60780 Poznan, Poland
来源：
CHEMICAL BIOLOGY & DRUG DESIGN | 2012年 / 79卷 / 03期
关键词：
drug design; drug discovery; natural product; therapeutic target; SODIUM COMPLEX; STEM-CELL; APOPTOSIS; IONOPHORE; TOXICITY; P21; NMR;
D O I：
10.1111/j.1747-0285.2011.01287.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Very recently, it has been shown that it is possible to selectively kill breast cancer stem cells using the ionophore antibiotic, salinomycin. Its ability to kill cancer stem cells and apoptosis-resistant cancer cells may define salinomycin as a novel anticancer drug.
引用
收藏
页码：235 / 238
页数：4
相关论文
共 50 条
  • [21] New candidate to combat drug-resistant bacteria
    Bagcchi, Sanjeet
    LANCET INFECTIOUS DISEASES, 2024, 24 (04): : e227 - e227
  • [22] Drug interaction between salinomycin and exogenous adrenaline in dogs
    Rajaian, H.
    Sadjedianfard, J.
    Nazifi, S.
    Amirizadeh, S.
    Saki, A.
    JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 2009, 32 : 84 - 84
  • [23] Combinatorial treatment of lung cancer cell lines and their spheroids-cancer stem cells with standard therapeutic drug and salinomycin
    Xiao, Z.
    Sperl, B.
    Ullrich, A.
    Knyazev, P.
    EUROPEAN JOURNAL OF CANCER, 2014, 50 : S190 - S190
  • [24] Erratum: A new platinum(II) compound anticancer drug candidate with selective cytotoxicity for breast cancer cells
    A Muscella
    C Vetrugno
    F P Fanizzi
    C Manca
    S A De Pascali
    S Marsigliante
    Cell Death & Disease, 2014, 5 : e1388 - e1388
  • [25] Bacterial Protein Azurin as a New Candidate Drug to Treat P-cadherin Overexpressing Breast Cancer
    Bernardes, N.
    Ribeiro, A. S.
    Mota, B.
    Estevens, T.
    Matos, R. G.
    Arraiano, C. M.
    Seruca, R.
    Paredes, J.
    Fialho, A. M.
    EUROPEAN JOURNAL OF CANCER, 2012, 48 : S255 - S255
  • [26] Cytotoxicity of anticancer candidate salinomycin and identification of its metabolites in rat cell cultures
    Radko, Lidia
    Olejnik, Malgorzata
    TOXICOLOGY IN VITRO, 2018, 52 : 314 - 320
  • [27] SALINOMYCIN - NEW MONOVALENT CATION IONOPHORE
    MITANI, M
    YAMANISHI, T
    MIYAZAKI, Y
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1975, 66 (04) : 1231 - 1236
  • [28] CCRK is a new candidate oncogene for colon cancer
    An, Xiaomeng
    Li, Ming
    Ng, Samuel
    Lin, Marie
    CANCER RESEARCH, 2006, 66 (08)
  • [29] Palbociclib - also a candidate drug for advanced canine mammary cancer
    Schoos, A.
    Wagner, D.
    Fux, D.
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2017, 390 : S65 - S66
  • [30] Analysis of the Differences in the Expression of mRNAs and miRNAs Associated with Drug Resistance in Endometrial Cancer Cells Treated with Salinomycin
    Januszyk, Piotr
    Januszyk, Krzysztof
    Wierzbik-Stronska, Magdalena
    Boron, Dariusz
    Grabarek, Beniamin
    CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2021, 22 (04) : 540 - 547
12345