Association of genetic risk factors with cognitive decline: the PATH through life project

被引：43
|
作者：
Andrews, Shea J. [1 ]
Das, Debjani [1 ]
Cherbuin, Nicolas [2 ]
Anstey, Kaarin J. [2 ]
Easteal, Simon [1 ]
机构：
[1] Australian Natl Univ, John Curtin Sch Med Res, Dept Genome Sci, Canberra, ACT 2601, Australia
[2] Australian Natl Univ, Res Sch Populat Hlth, Ctr Res Ageing Hlth & Wellbeing, Canberra, ACT, Australia
来源：
NEUROBIOLOGY OF AGING | 2016年 / 41卷
基金：
澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;
关键词：
Alzheimer's disease; Cognitive decline; SNPs; Genetic risk scores; Population-based study; GENOME-WIDE ASSOCIATION; ALZHEIMER-DISEASE; AGE; GENOTYPE; NEUROPATHOLOGY; INTELLIGENCE; ABILITY; PICALM; BIN1; CLU;
D O I：
10.1016/j.neurobiolaging.2016.02.016
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
We examined the association of 28 single nucleotide polymorphisms (SNPs), previously associated with dementia or cognitive performance, with tests assessing episodic memory, working memory, vocabulary, and perceptual speed in 1689 nondemented older Australians of European ancestry. In addition to testing each variant individually, we assessed the collective association of the 12-risk SNPs for late-onset Alzheimer's disease using weighted and unweighted genetic risk scores. Significant associations with cognitive performance were observed for APOE epsilon 4 allele, ABCA7-rs3764650, CR1-rs3818361, MS4A4E-rs6109332, BDNF-rs6265, COMT-rs4680, CTNNBL-rs6125962, FRMD4A-rs17314229, FRMD4A-rs17314229, intergenic SNP chrX-rs12007229, PDE7A-rs10808746, SORL1-rs668387, and ZNF224-rs3746319. In addition, the weighted genetic risk score was associated with worse performance on episodic memory. The identification of genetic risk factors, that act individually or collectively, may help in screening for people with elevated risk of cognitive decline and for understanding the biological pathways that underlie cognitive decline. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：150 / 158
页数：9
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