Cell Surface Proteins in Hepatocellular Carcinoma: From Bench to Bedside

被引：8
|
作者：
Siracusano, Gabriel [1 ]
Tagliamonte, Maria [2 ]
Buonaguro, Luigi [2 ]
Lopalco, Lucia [1 ]
机构：
[1] Ist Sci San Raffaele, Div Immunol Transplantat & Infect Dis, Milan 20132, Italy
[2] Ist Nazl Studio & Cura Tumori IRCCS, Fdn Pascale, Canc Immunoregulat Unit, Naples 80131, Italy
来源：
VACCINES | 2020年 / 8卷 / 01期
基金：
欧盟地平线“2020”;
关键词：
hepatocellular carcinoma; cell surface proteins; biomarker; therapeutic target; clinical trial; EPITHELIAL-MESENCHYMAL TRANSITION; PROSTAGLANDIN E-2 PROMOTES; LIVER-CANCER; POOR-PROGNOSIS; IN-VITRO; GLYPICAN-3; EXPRESSION; ADENOVIRUS RECEPTOR; HUMANIZED ANTIBODY; THERAPEUTIC TARGET; INVASIVE ABILITY;
D O I：
10.3390/vaccines8010041
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Cell surface proteins act as the go-between in carrying the information from the extracellular environment to the intracellular signaling proteins. However, these proteins are often deregulated in neoplastic diseases, including hepatocellular carcinoma. This review discusses several recent studies that have investigated the role of cell surface proteins in the occurrence and progression of HCC, highlighting the possibility to use them as biomarkers of the disease and/or targets for vaccines and therapeutics.
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收藏
页数：23
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