Chemoproteomic profiling of protein-metabolite interactions

被引：24
|
作者：
Qin, Wei [1 ,2 ,3 ,4 ]
Yang, Fan [1 ,2 ,3 ,5 ]
Wang, Chu [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Peking Univ, Synthet & Funct Biomol Ctr, Beijing, Peoples R China
[2] Peking Univ, Beijing Natl Lab Mol Sci, Beijing, Peoples R China
[3] Peking Univ, Minist Educ, Key Lab Bioorgan Chem & Mol Engn, Beijing, Peoples R China
[4] Peking Univ, Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
[5] Peking Univ, Coll Chem & Mol Engn, Beijing, Peoples R China
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 2020年 / 54卷
基金：
中国国家自然科学基金;
关键词：
Chemoproteomics; Protein-metabolite interactions; Post-translational modifications; Non-covalent binding; Activity-based protein profiling; COVALENT LIGAND DISCOVERY; REACTIVITY; MAP; CYSTEINES; DRUG;
D O I：
10.1016/j.cbpa.2019.11.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Small molecule metabolites play important roles in regulating protein functions, which are acted through either covalent nonenzymatic post-translational modifications or non-covalent binding interactions. Chemical proteomic strategies can help delineate global landscapes of cellular protein-metabolite interactions and provide molecular insights about their mechanisms of action. In this review, we summarized the recent progress in developments and applications of chemoproteomic strategies to profile protein-metabolite interactions.
引用
收藏
页码：28 / 36
页数：9
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