Mussel-Inspired Carboxymethyl Chitosan Hydrogel Coating of Titanium Alloy with Antibacterial and Bioactive Properties

被引:13
|
作者
Ren, Yanru [1 ,2 ]
Qin, Xiaoyan [1 ]
Barbeck, Mike [2 ]
Hou, Yi [1 ]
Xu, Haijun [1 ]
Liu, Luo [1 ]
Liu, Chaoyong [1 ]
机构
[1] Beijing Univ Chem Technol, Beijing Bioproc Key Lab, Beijing 100029, Peoples R China
[2] Tech Univ Berlin, Inst Mat Sci & Technol, Hardenbergstr 40,Sekr BA3, D-10623 Berlin, Germany
基金
中国国家自然科学基金;
关键词
carboxymethyl chitosan; gallic acid; titanium alloy; DMTMM; HRP/H2O2; catechol group; hydrogel coating; antibacterial; SILVER NANOPARTICLES; CATECHOL; ANTIOXIDANT; ACID;
D O I
10.3390/ma14226901
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Infection-related titanium implant failure rates remain exceedingly high in the clinic. Functional surface coating represents a very promising strategy to improve the antibacterial and bioactive properties of titanium alloy implants. Here, we describe a novel bioactive surface coating that consists of a mussel-inspired carboxymethyl chitosan hydrogel loaded with silver nanoparticles (AgNPs) to enhance the bioactive properties of the titanium alloy. The preparation of hydrogel is based on gallic acid grafted carboxymethyl chitosan (CMCS-GA) catalyzed by DMTMM (4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride). To build a firm bonding between the hydrogel and titanium alloy plate, a polydopamine layer was introduced onto the surface of the titanium alloy. With HRP/H2O2 catalysis, CMCS-GA can simply form a firm gel layer on the titanium alloy plate through the catechol groups. The surface properties of titanium alloy were characterized by scanning electron microscope (SEM), X-ray photoelectron spectroscopy (XPS), and water contact angle. Silver nanoparticles were loaded into the gel layer by in situ reduction to enhance the antibacterial properties. In vitro antibacterial and cell viability experiments showed that the AgNPs-loaded Ti-gel possesses excellent antibacterial properties and did not affect the proliferation of rabbit mesenchymal stem cells (MSCs).
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页数:11
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