Mussel-Inspired Carboxymethyl Chitosan Hydrogel Coating of Titanium Alloy with Antibacterial and Bioactive Properties

被引:12
|
作者
Ren, Yanru [1 ,2 ]
Qin, Xiaoyan [1 ]
Barbeck, Mike [2 ]
Hou, Yi [1 ]
Xu, Haijun [1 ]
Liu, Luo [1 ]
Liu, Chaoyong [1 ]
机构
[1] Beijing Univ Chem Technol, Beijing Bioproc Key Lab, Beijing 100029, Peoples R China
[2] Tech Univ Berlin, Inst Mat Sci & Technol, Hardenbergstr 40,Sekr BA3, D-10623 Berlin, Germany
基金
中国国家自然科学基金;
关键词
carboxymethyl chitosan; gallic acid; titanium alloy; DMTMM; HRP/H2O2; catechol group; hydrogel coating; antibacterial; SILVER NANOPARTICLES; CATECHOL; ANTIOXIDANT; ACID;
D O I
10.3390/ma14226901
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Infection-related titanium implant failure rates remain exceedingly high in the clinic. Functional surface coating represents a very promising strategy to improve the antibacterial and bioactive properties of titanium alloy implants. Here, we describe a novel bioactive surface coating that consists of a mussel-inspired carboxymethyl chitosan hydrogel loaded with silver nanoparticles (AgNPs) to enhance the bioactive properties of the titanium alloy. The preparation of hydrogel is based on gallic acid grafted carboxymethyl chitosan (CMCS-GA) catalyzed by DMTMM (4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride). To build a firm bonding between the hydrogel and titanium alloy plate, a polydopamine layer was introduced onto the surface of the titanium alloy. With HRP/H2O2 catalysis, CMCS-GA can simply form a firm gel layer on the titanium alloy plate through the catechol groups. The surface properties of titanium alloy were characterized by scanning electron microscope (SEM), X-ray photoelectron spectroscopy (XPS), and water contact angle. Silver nanoparticles were loaded into the gel layer by in situ reduction to enhance the antibacterial properties. In vitro antibacterial and cell viability experiments showed that the AgNPs-loaded Ti-gel possesses excellent antibacterial properties and did not affect the proliferation of rabbit mesenchymal stem cells (MSCs).
引用
收藏
页数:11
相关论文
共 50 条
  • [1] Rapidly degrading and mussel-inspired multifunctional carboxymethyl chitosan/montmorillonite hydrogel for wound hemostasis
    Ouyang, Yongliang
    Zhao, Yizhou
    Zheng, Xiaoyi
    Zhang, Yao
    Zhao, Jiulong
    Wang, Shige
    Gu, Yubei
    [J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2023, 242
  • [2] Mussel-Inspired Polymer-Based Coating Technology for Antifouling and Antibacterial Properties
    Imbia, Adel S.
    Ounkaew, Artjima
    Mao, Xiaohui
    Zeng, Hongbo
    Liu, Yang
    Narain, Ravin
    [J]. LANGMUIR, 2024, 40 (21) : 10957 - 10965
  • [3] Synthesis and characterisation of a mussel-inspired hydrogel film coating for biosensors
    Millican, Jonathan M.
    Bittrich, Eva
    Caspari, Anja
    Poschel, Kathrin
    Drechsler, Astrid
    Freudenberg, Uwe
    Ryan, Timothy G.
    Thompson, Richard L.
    Pospiech, Doris
    Hutchings, Lian R.
    [J]. EUROPEAN POLYMER JOURNAL, 2021, 153
  • [4] Synthesis and characterisation of a mussel-inspired hydrogel film coating for biosensors
    Millican, Jonathan M.
    Bittrich, Eva
    Caspari, Anja
    Pöschel, Kathrin
    Drechsler, Astrid
    Freudenberg, Uwe
    Ryan, Timothy G.
    Thompson, Richard L.
    Pospiech, Doris
    Hutchings, Lian R.
    [J]. European Polymer Journal, 2021, 153
  • [5] Mussel-inspired adhesive zwitterionic composite hydrogel with antioxidant and antibacterial properties for wound healing
    Wang, Shiyu
    Liu, Ruiqi
    Bi, Siwei
    Zhao, Xueshan
    Zeng, Guixiang
    Li, Xiaoyi
    Wang, Haibo
    Gu, Jun
    [J]. COLLOIDS AND SURFACES B-BIOINTERFACES, 2022, 220
  • [6] Surface Characteristics of Mussel-inspired Polydopamine Coating on Titanium Substrates
    姜玲
    JIN Guangchun
    KANG Jiyeon
    YU Lingmin
    YOON Wookang
    LIM MyungJin
    PAR K Ilsong
    LEE Minho
    JIN Dongchun
    [J]. Journal of Wuhan University of Technology(Materials Science), 2014, 29 (01) : 197 - 200
  • [7] Surface characteristics of mussel-inspired polydopamine coating on titanium substrates
    Ling Jiang
    Guangchun Jin
    Jiyeon Kang
    Lingmin Yu
    Wookang Yoon
    MyungJin Lim
    Ilsong Par K
    Minho Lee
    Dongchun Jin
    [J]. Journal of Wuhan University of Technology-Mater. Sci. Ed., 2014, 29 : 197 - 200
  • [8] Surface characteristics of mussel-inspired polydopamine coating on titanium substrates
    Jiang Ling
    Jin Guangchun
    Kang, Jiyeon
    Yu Lingmin
    Yoon, Wookang
    Lim, MyungJin
    Par, K. Ilsong
    Lee, Minho
    Jin Dongchun
    [J]. JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION, 2014, 29 (01): : 197 - 200
  • [9] A mussel-inspired carboxymethyl cellulose hydrogel with enhanced adhesiveness through enzymatic crosslinking
    Zhong, Yujie
    Wang, Jie
    Yuan, Zhenyu
    Wang, Yu
    Xi, Zhenhao
    Li, Li
    Liu, Zhiyong
    Guo, Xuhong
    [J]. COLLOIDS AND SURFACES B-BIOINTERFACES, 2019, 179 : 462 - 469
  • [10] Mussel-Inspired Adhesive, Antibacterial, and Stretchable Composite Hydrogel for Wound Dressing
    Chen, Ying
    Fan, Xiaokun
    Lu, Jiawei
    Liu, Xin
    Chen, Jin
    Chen, Yi
    [J]. MACROMOLECULAR BIOSCIENCE, 2023, 23 (01)