Structural variation discovery with next-generation sequencing

被引：0
|
作者：
Gao, Jingyang [1 ]
Qi, Fei [1 ]
Guan, Rui [1 ]
机构：
[1] Beijing Univ Chem Technol, Coll Informat Sci & Technol, Beijing 100029, Peoples R China
来源：
2013 2ND INTERNATIONAL SYMPOSIUM ON INSTRUMENTATION AND MEASUREMENT, SENSOR NETWORK AND AUTOMATION (IMSNA) | 2013年
关键词：
structural variation; sequencing-based; bioinformatics; COMBINATORIAL ALGORITHMS; SHORT-READ; GENOME; INSERTIONS; DELETIONS; VARIANTS;
D O I：
暂无
中图分类号：
TP [自动化技术、计算机技术];
学科分类号：
0812 ;
摘要：
One of the most important direction of bioinformatics is the genome structural variation discovery. In this paper, firstly we explain four sequencing-based methods, i.e., Read-pair, Read-depth, Split-read and Assembly. Secondly, the advantage and disadvantage of the approaches are discussed. Thirdly, the combination of the methods is proved to be a better one. Finally, a novel combined strategy was analyzed that will be the direction of the future.
引用
收藏
页码：709 / 711
页数：3
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