Synthesis and Anti-Fungal Activity of Seven Oleanolic Acid Glycosides

被引：12

作者：

Zhao, Hanqing ^{[1
]}

Zong, Guanghui ^{[1
]}

Zhang, Jianjun ^{[1
]}

Wang, Daoquan ^{[1
]}

Liang, Xiaomei ^{[1
]}

机构：

[1] China Agr Univ, Dept Appl Chem, Key Lab Pesticide Chem & Applicat Technol, Beijing 100193, Peoples R China

来源：

MOLECULES | 2011年 / 16卷 / 02期

关键词：

synthesis; oleanolic acid; glycoconjugate; anti-fungal activity; TRITERPENOID SAPONINS; SILICA-GEL;

D O I：

10.3390/molecules16021113

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In order to develop potential anti-fungal agents, seven glycoconjugates composed of alpha-L-rhamnose, 6-deoxy-alpha-L-talose, beta-D-galactose, alpha-D-mannose, beta-D-xylose-(1 -> 4)-6-deoxy-alpha-L-talose, beta-D-galactose-(1 -> 4)-alpha-L-rhamnose, beta-D-galactose-(1 -> 3)-beta-D-xylose-(1 -> 4)-6-deoxy-alpha-L-talose as the glycone and oleanolic acid as the aglycone were synthesized in an efficient and practical way using glycosyl trichloroacetimidates as donors. The structures of the new compounds were confirmed by MS, H-1-NMR and C-13-NMR. Preliminary studies based on means of mycelium growth rate, indicated that all the compounds possess certain fungicidal activity against Sclerotinia sclerotiorum (Lib.) de Bary, Rhizoctonia solani Kuhn, Botrytis cinerea Pers and Phytophthora parasitica Dast.

引用

页码：1113 / 1128

页数：16

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