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Southern Univ Sci & Technol, Sch Med, Dept Biochem,Shenzhen Key Lab Cell Microenvironm, Guangdong Prov Key Lab Cell Microenvironm & Dis Re, Shenzhen 518055, Peoples R China Huazhong Univ Sci & Technol, Union Shenzhen Hosp, Dept Orthoped, 89 Taoyuan Rd, Shenzhen 518000, Peoples R China