beta-(2 ' -Furyl)-acrylophenone dibromide (Ia-c) react with hydroxylamine hydrochloride in pyridine to give 3-(2 " -hydroxy-3 " -substituted-5 " -chlorophenyl)-5-(2 ' -furyl)-isoxazoles (IIa-c) while in methanol the corresponding 3-(2 ' -furyl)-5-(2 " -hydroxy-3 " -substituted-5 " -chlorophenyl) isoxazoles (IIIa-c) are obtained contrary to the isomerization of isoxazoles (IIa-c) in pyridine.
机构:
Islamic Azad Univ, Dept Appl Chem, Organ Chem Res Lab, Tabri Branch, Tabriz, IranIslamic Azad Univ, Dept Appl Chem, Organ Chem Res Lab, Tabri Branch, Tabriz, Iran