1H high-resolution magic angle spinning NMR spectroscopy for the investigation of a Ras lipopeptide in a lipid membrane

A double lipid-modified peptide which mimics the seven amino acids of the C terminus of the N-Ras protein has been investigated by high-resolution 1H magic angle spinning NMR spectroscopy. The axially symmetric motion of the peptide in the bilayer decreases the NMR line widthes, which facilitates signal assignment and localization of the peptide in the membrane (see schematic representation).