Hippocampal AP5 treatment impairs both spatial working and reference memory in radial maze performance in rats

被引：15

作者：

Yamada, Kazuo ^{[1
]}

Shimizu, Makoto ^{[1
]}

Kawabe, Kouichi ^{[2
]}

Ichitani, Yukio ^{[1
]}

机构：

[1] Univ Tsukuba, Inst Psychol & Behav Neurosci, Tsukuba, Ibaraki 3058577, Japan

[2] Osaka City Univ, Grad Sch Literature & Human Sci, Sumiyoshi Ku, Osaka 5588585, Japan

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2015年 / 758卷

基金：

日本学术振兴会;

关键词：

NMDA receptor; AP5; Hippocampus; Spatial working memory; Spatial reference memory; Radial maze; Rat; ASPARTATE RECEPTOR ANTAGONIST; LONG-TERM POTENTIATION; CA3 NMDA RECEPTORS; DIFFERENTIAL CONTRIBUTION; SELECTIVE IMPAIRMENT; SYNAPTIC PLASTICITY; TASK; BLOCKADE; CORTEX;

D O I：

10.1016/j.ejphar.2015.03.080

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The possible involvement of hippocampal N-methyl-D-aspartate (NMDA) receptors in spatial reference and working memory was investigated. Rats were first trained in a four-baited/four-unbaited version of the eight-arm radial maze task in which only predetermined four arms for each rat were baited with a Food pellet. After rats reached the learning criterion, their performance was tested under the treatment of a NMDA antagonist, AP5 (D,L-2-amino-5-phosphonopentanoic acid, 20-40 nmol), or vehicle into the dorsal hippocampus through the bilaterally implanted guide cannulae. AP5 produced dose-dependent increments on both reference and working memory errors, but did not have any effect on the running speed. Additionally, there were significant correlations between the number of trials to criterion in acquisition and the number of reference and working memory errors induced by AP5 treatment. The results suggest that hippocampal NMDA receptors are involved in both spatial reference and working memory. (C) 2015 Elsevier By. All rights reserved,

引用

页码：137 / 141

页数：5

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