BLOCKADE OF HIPPOCAMPAL NICOTINIC RECEPTORS IMPAIRS WORKING MEMORY BUT NOT REFERENCE MEMORY IN RATS

被引：84
|
作者：
OHNO, M
YAMAMOTO, T
WATANABE, S
机构：
[1] Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyushu University, Higashi-ku, Fukuoka, 812
来源：
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1993年 / 45卷 / 01期
关键词：
HIPPOCAMPUS; NICOTINIC RECEPTOR; MECAMYLAMINE; WORKING MEMORY; REFERENCE MEMORY; RUNWAY TASK; RAT;
D O I：
10.1016/0091-3057(93)90091-7
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
In a three-panel runway task, intrahippocampal injection of the nicotinic receptor antagonist, mecamylamine (10 and 8 mug/side), significantly increased the number of errors (attempts to pass through two incorrect panels of the three panel-gates at four choice points) in a test of working memory. This increase in errors also occurred after rats were given IP mecamylamine (10 mg/kg). Mecamylamine did not affect the number of errors in a test of reference memory whether it was given at doses up to 18 mug/side intrahippocampally or up to 10 mg/kg IP. These results suggest that mechanisms mediated by hippocampal nicotinic receptors play a role in working memory but not in reference memory.
引用
收藏
页码：89 / 93
页数：5
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