Cancer intervention;
Immunology;
Skin cancer;
Depressive disorder;
Surgical oncology;
AMYLOIDOSIS;
D O I:
10.1136/bcr-2022-249873
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
A middle-aged woman presented with a mechanical fall. Physical examination revealed a massive purulent ulcerated lesion spanning her entire back and axilla, which had reportedly been brewing for over a decade. Punch biopsy revealed infiltrative basal cell carcinoma. She was treated with Vismodegib, with a remarkable decrease in the size of the cancer. However, surveillance imaging after 6 months of treatment revealed new bone metastases. In the setting of progressive disease, medical therapy was switched to cemiplimab instead. Basal cell carcinoma is commonly known as a benign tumour of the skin, rarely larger than 5 cm. Here, we discuss the entity of metastatic super giant basal cell carcinoma; this case is one of the largest reported lesions. As locoregional therapy, such as surgery is sometimes not appropriate for such advanced lesions, we discuss the current forefront of therapy including oral hedgehog pathway and check point inhibitors.
机构:
Univ Adelaide, Forens Sci SA, Adelaide, SA, Australia
Univ Adelaide, Adelaide Med Sch, Level 2,Room N237,Frome Rd, Adelaide, SA 5005, AustraliaUniv Adelaide, Forens Sci SA, Adelaide, SA, Australia
Byard, Roger W.
论文数: 引用数:
h-index:
机构:
Wills, Stephen
Gilbert, John D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Adelaide, Forens Sci SA, Adelaide, SA, AustraliaUniv Adelaide, Forens Sci SA, Adelaide, SA, Australia