Metastatic insidious super giant basal cell carcinoma

被引:1
|
作者
Ahmed, Maryam [1 ]
Muradashvili, Tinatin [1 ]
Soliman, Sara [1 ]
Ghaly, Medhat [1 ]
机构
[1] Yale Univ, Sch Med, Yale Waterbury Internal Med Residency, Waterbury, CT 06706 USA
关键词
Cancer intervention; Immunology; Skin cancer; Depressive disorder; Surgical oncology; AMYLOIDOSIS;
D O I
10.1136/bcr-2022-249873
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A middle-aged woman presented with a mechanical fall. Physical examination revealed a massive purulent ulcerated lesion spanning her entire back and axilla, which had reportedly been brewing for over a decade. Punch biopsy revealed infiltrative basal cell carcinoma. She was treated with Vismodegib, with a remarkable decrease in the size of the cancer. However, surveillance imaging after 6 months of treatment revealed new bone metastases. In the setting of progressive disease, medical therapy was switched to cemiplimab instead. Basal cell carcinoma is commonly known as a benign tumour of the skin, rarely larger than 5 cm. Here, we discuss the entity of metastatic super giant basal cell carcinoma; this case is one of the largest reported lesions. As locoregional therapy, such as surgery is sometimes not appropriate for such advanced lesions, we discuss the current forefront of therapy including oral hedgehog pathway and check point inhibitors.
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页数:5
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