Single living cell refractometry using FBG-based resonant cavity

被引：0

作者：

Chin, L. K. ^{[1
]}

Lim, C. S. ^{[2
]}

Yap, P. H. ^{[3
]}

Ng, J. H. ^{[4
]}

Hao, J. Z. ^{[4
]}

Takahashi, S. ^{[4
]}

Liu, A. Q. ^{[1
]}

机构：

[1] Nanyang Technol Univ, Sch Elect & Elect Engn, Singapore, Singapore

[2] Nanyang Technol Univ, Sch Chem & Biomed Engn, Singapore, Singapore

[3] DSO Natl Labs, Def Med & Environmental Res Inst, Singapore, Singapore

[4] Inst Infocomm Res, Singapore, Singapore

来源：

TRANSDUCERS '07 & EUROSENSORS XXI, DIGEST OF TECHNICAL PAPERS, VOLS 1 AND 2 | 2007年

关键词：

fiber Bragg gratings; single cell measurement; buffer modulation and refractive index;

D O I：

暂无

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

This paper reports a single cell refractometer consists of FBG fiber-based resonant cavity by employing buffer modulation method. In this biophotonic chip, single cell is trapped optically in the cavity, and the transmission spectral shifts due to the change of surrounding buffer, without and with cell, are used to determine the cell's refractive index (RI) and size. The measurement shows that MDCK cell has an effective RI of 1.383 at a precision of 0.1%. Moreover, the measurement method with optical trapping eliminates uncertain factors and prevents cell damage. The chip is promising for label-free cell measurement and further cell analysis.

引用

页数：2

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