The therapeutic role of ivabradine in heart failure

被引：26
|
作者：
Badu-Boateng, Charles [2 ]
Jennings, Robert [2 ]
Hammersley, Daniel [1 ]
机构：
[1] Kings Coll Hosp NHS Fdn Trust, Dept Cardiol, Denmark Hill, London SE5 9RS, England
[2] Frimley Pk Hosp, Dept Med, Frimley, Camberley, England
来源：
THERAPEUTIC ADVANCES IN CHRONIC DISEASE | 2018年 / 9卷 / 11期
关键词：
drug therapy; heart failure; ivabradine; CORONARY-ARTERY-DISEASE; VENTRICULAR SYSTOLIC DYSFUNCTION; QUALITY-OF-LIFE; I-F INHIBITOR; RATE REDUCTION; CARDIAC-RHYTHM; OUTCOMES; MORTALITY; METAANALYSIS; BEAUTIFUL;
D O I：
10.1177/2040622318784556
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Heart failure represents a major global cause of morbidity and mortality. Ivabradine is a selective funny current (I-f) inhibitor, which acts on the sinoatrial node, resulting in a reduction in heart rate. Ivabradine is currently licensed for use in patients with symptomatic heart failure with reduced ejection fraction and a heart rate persistently at least 70 beats per minute in spite of otherwise optimal prognostic heart failure pharmacotherapy. In this review article, we examine the mechanism of action of ivabradine, evaluate the clinical trials underpinning its application in heart failure and discuss its current recommended clinical use in this capacity.
引用
收藏
页码：199 / 207
页数：9
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