Intracellular pathways involved in TNF-α and superoxide anion release by Aβ(1-42)-stimulated primary human macrophages

被引：15
|
作者：
Smits, HA [1 ]
de Vos, NM [1 ]
Wat, JWY [1 ]
van der Bruggen, T [1 ]
Verhoef, J [1 ]
Nottet, HSLM [1 ]
机构：
[1] Univ Utrecht, Med Ctr Utrecht, Eijkman Winkler Inst, Sect Neuroimmunol, NL-3584 CX Utrecht, Netherlands
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2001年 / 115卷 / 1-2期
关键词：
Alzheimer's disease; beta-amyloid; kinases; signal transduction; TNF-alpha;
D O I：
10.1016/S0165-5728(01)00254-5
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In this study, the intracellular signal transduction pathways leading to the production of TNF-alpha and superoxide anions by amyloid-beta -stimulated primary human monocyte-derived macrophages was investigated. Using Western blotting and specific inhibitors it is shown that both ERK 1/2 and p38 MAPK signal transduction pathways as well as PKC are involved in the amyloid-beta -stimulated superoxide anion production. In contrast. only ERK 1/2 MAPK seems to be involved in TNF-alpha production: questioning the connection between PKC and ERK 1/2 activation. Our results suggest the use of ERK 1/2 MAPK inhibitors in the prevention of macrophage activation in the context of Alzheimer's disease. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：144 / 151
页数：8
相关论文
共 38 条
  • [31] Intracellular signaling pathways involved in the release of IL-4 and VEGF from human keratinocytes by activation of kinin B1 receptor: functional relevance to angiogenesis
    Mejia, Astrid J.
    Matus, Carola E.
    Pavicic, Francisca
    Concha, Miguel
    Ehrenfeld, Pamela
    Figueroa, Carlos D.
    ARCHIVES OF DERMATOLOGICAL RESEARCH, 2015, 307 (09) : 803 - 817
  • [32] Intracellular signaling pathways involved in the release of IL-4 and VEGF from human keratinocytes by activation of kinin B1 receptor: functional relevance to angiogenesis
    Astrid J. Mejia
    Carola E. Matus
    Francisca Pavicic
    Miguel Concha
    Pamela Ehrenfeld
    Carlos D. Figueroa
    Archives of Dermatological Research, 2015, 307 : 803 - 817
  • [33] Suppression of Th2 chemokines by crocin via blocking of ERK-MAPK/NF-B/STAT1 signalling pathways in TNF-/IFN--stimulated human epidermal keratinocytes
    Park, Ji-Hyun
    Lee, Ki Yong
    Park, Byoungduck
    Yoon, Jaewoo
    EXPERIMENTAL DERMATOLOGY, 2015, 24 (08) : 634 - 636
  • [34] Fucosterol Isolated from Dietary Brown Alga Sargassum horneri Protects TNF-α/IFN-γ-Stimulated Human Dermal Fibroblasts Via Regulating Nrf2/HO-1 and NF-κB/MAPK Pathways
    Kirindage, Kirinde Gedara Isuru Sandanuwan
    Jayasinghe, Arachchige Maheshika Kumari
    Han, Eui-Jeong
    Jee, Youngheun
    Kim, Hyun-Jin
    Do, Sun Gil
    Fernando, Ilekuttige Priyan Shanura
    Ahn, Ginnae
    ANTIOXIDANTS, 2022, 11 (08)
  • [35] Adiponectin-stimulated CXCL8 release in primary human hepatocytes is regulated by ERK1/ERK2, p38 MAPK, NF-κB, and STAT3 signaling pathways
    Wanninger, Josef
    Neumeier, Markus
    Weigert, Johanna
    Bauer, Sabrina
    Weiss, Thomas S.
    Schaeffler, Andreas
    Krempl, Corinna
    Bleyl, Cornelia
    Aslanidis, Charalampos
    Schoelmerich, Juergen
    Buechler, Christa
    AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2009, 297 (03): : G611 - G618
  • [36] Selective immaturity of Toll-Like receptor pathways in human newborns:: Impaired cord blood TNF-α release in response to ligands of TLRs 1-4 and TLR6-7, with relatively preserved response to the imidazoquinoline compound R-848 (TLR7/8)
    Levy, O
    Zarember, KA
    Cywes, C
    Roy, RM
    Godowski, PJ
    Wessels, MR
    PEDIATRIC RESEARCH, 2004, 55 (04) : 391A - 391A
  • [37] Adiponectin-stimulated CXCL8 release in primary human hepatocytes is regulated by ERK1/ERK2, p38 MAPK, NF-κB, and STAT3 signaling pathways (vol 297, pg G611, 2009)
    Wanninger, J.
    Neumeier, M.
    Weigert, J.
    Bauer, S.
    Weiss, T. S.
    Schaeffler, A.
    Krempl, C.
    Bleyl, C.
    Aslanidis, C.
    Schoelmerich, J.
    Buechler, C.
    AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2012, 302 (03): : G406 - G406
  • [38] Pamidronate and 1,25-dihydroxy-vitamin-D3 inhibit tumor necrosis factor-alpha (TNF-α)- and wear debris-induced interleukin-6 (IL-6) release and recover suppressed type I collagen synthesis in bone marrow-derived primary human osteoblasts.
    Vermes, C
    Raman, C
    Dobai, J
    Andersson, GBJ
    An, H
    Jacobs, JJ
    Glant, TT
    ARTHRITIS AND RHEUMATISM, 2001, 44 (09): : S355 - S355
1234