Dietary intake of flavonoid subclasses and risk of type 2 diabetes in prospective cohort studies: A dose-response meta-analysis

Flavonoids intake has been linked to risk of type 2 diabetes theoretically, but the findings were conflicting from observational studies. Results from the recent meta-analysis suggested a moderate favorable effect of total dietary fiavonoids consumption on type 2 diabetes risk. However, the relationship, if exists, between total dietary flavonoids consumption and type 2 diabetes risk is unclear, especially further in the association between flavonoid subclasses and risk of type 2 diabetes. Thus, the dose response relationship was assessed by restricted cubic spline model and multivariate random-effect meta regression. Among flavonoid subclasses, protective effects were obtained for intakes of fiavonols, flavan-3-ols, isoflavones and anthocyanidins in high vs. low analysis and dose response analysis. (C) 2018 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.