The road ahead for health and lifespan interventions

被引：57

作者：

Gonzalez-Freire, Marta ^{[1
,2
]}

Diaz-Ruiz, Alberto ^{[1
,3
]}

Hauser, David ^{[1
]}

Martinez-Romero, Jorge ^{[4
]}

Ferrucci, Luigi ^{[1
]}

Bernier, Michel ^{[1
]}

de Cabo, Rafael ^{[1
]}

机构：

[1] NIA, Translat Gerontol Branch, Biomed Res Ctr, NIH, Baltimore, MD 21224 USA

[2] Fundacio Inst Invest Sanitaria Illes Balears IdIS, Cardiovasc & Metab Dis Grp, Palma De Mallorca, Spain

[3] CEI UAM CSIC, Madrid Inst Adv Studies IMDEA Food, Precis Nutr & Aging, Nutr Intervent Grp, Madrid, Spain

[4] UAM, CEI, IMDEA Food, Precis Nutr & Canc Program,CSIC,Mol Oncol & Nutr, Madrid, Spain

来源：

AGEING RESEARCH REVIEWS | 2020年 / 59卷

基金：

美国国家卫生研究院;

关键词：

Lifespan; Healthspan; Aging; anti-aging; Longevity; Frailty; Translation; MIGRATION INHIBITORY FACTOR; DIETARY METHIONINE RESTRICTION; TARGETED ANTIOXIDANT MITOQ; GROWTH-FACTOR; 21; CALORIC RESTRICTION; SIRT1; ACTIVATOR; SKELETAL-MUSCLE; TRYPTOPHAN RESTRICTION; PROGENITOR CELLS; DOUBLE-BLIND;

D O I：

10.1016/j.arr.2020.101037

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Aging is a modifiable risk factor for most chronic diseases and an inevitable process in humans. The development of pharmacological interventions aimed at delaying or preventing the onset of chronic conditions and other age-related diseases has been at the forefront of the aging field. Preclinical findings have demonstrated that species, sex and strain confer significant heterogeneity on reaching the desired health- and lifespan-promoting pharmacological responses in model organisms. Translating the safety and efficacy of these interventions to humans and the lack of reliable biomarkers that serve as predictors of health outcomes remain a challenge. Here, we will survey current pharmacological interventions that promote lifespan extension and/or increased healthspan in animals and humans, and review the various anti-aging interventions selected for inclusion in the NIA's Interventions Testing Program as well as the ClinicalTrials.gov database that target aging or age-related diseases in humans.

引用

页数：19

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