Posaconazole as salvage therapy in patients with chronic granulomatous disease and invasive filamentous fungal infection

被引：104

作者：

Segal, BH

Barnhart, LA

Anderson, VL

Walsh, TJ

Malech, HL

Holland, SM

机构：

[1] NIAID, Lab Clin Infect Dis, NIH, Bethesda, MD 20892 USA

[2] Roswell Pk Canc Inst, Dept Med, Div Infect Dis, Buffalo, NY 14263 USA

[3] Roswell Pk Canc Inst, Dept Immunol, Div Infect Dis, Buffalo, NY 14263 USA

[4] NIAID, Host Def Lab, NIH, Bethesda, MD 20892 USA

[5] NCI, Immunocompromised Host Sect, Pediat Oncol Branch, NIH, Bethesda, MD 20892 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2005年 / 40卷 / 11期

关键词：

D O I：

10.1086/430068

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chronic granulomatous disease (CGD) is characterized by life-threatening bacterial and fungal infections. Treatment with posaconazole led to a complete response in 7 of 8 patients with CGD with invasive mold infections ( 7 proven cases and 1 possible case) after failure or intolerance of treatment with standard antifungal agents. In this preliminary study, salvage treatment with posaconazole was safe and effective.

引用

页码：1684 / 1688

页数：5

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