Synthesis and biological activity of analogues of ptilomycalin A

被引：24

作者：

Black, GP

Coles, SJ

Hizi, A

Howard-Jones, AG

Hursthouse, MB

McGown, AT

Loya, S

Moore, CG

Murphy, PJ ^{[1
]}

Smith, NK

Walshe, NDA

机构：

[1] Univ Wales, Dept Chem, Bangor LL57 2UW, Gwynedd, Wales

[2] Pfizer Ltd, Cent Res, Sandwich CT13 9NJ, Kent, England

[3] Tel Aviv Univ, Sackler Sch Med, Dept Cell Biol & Histol, Tel Aviv, Israel

[4] Christie Hosp NHS Trust, Paterson Inst Canc Res, Christie CRC Res Ctr, Manchester M20 4BX, Lancs, England

[5] Univ Southampton, Dept Chem, Southampton SO17 1BJ, Hants, England

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 19期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0040-4039(01)00400-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Benzo-fused model compounds 21a and 21b, resembling in structure the marine metabolite ptilomycalin A, were prepared and were shown to display significant activity against a series of cancer cell lines and to also possess a significant activity against the DNA polymerase activity of the reverse transcriptase of human immunodeficiency virus type 1 (HIV-1 RT). (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：3377 / 3381

页数：5

共 50 条

[31] Senolytic activity of piperlongumine analogues: Synthesis and biological evaluation
Liu, Xingui
Wang, Yingying
Zhang, Xuan
Gao, Zhengya
Zhang, Suping
Shi, Peizhong
Zhang, Xin
Song, Lin
Hendrickson, Howard
Zhou, Daohong
Zheng, Guangrong
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 26 (14) : 3925 - 3938
[32] Structure, biological activity and synthesis of polyamine analogues and conjugates
Karigiannis, G
Papaioannou, D
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2000, 2000 (10) : 1841 - 1863
[33] Synthesis and biological activity of simplified belactosin C analogues
de Meijere, Armin
Korotkov, Vadim S.
Lygin, Alexander V.
Larionov, Oleg V.
Sokolov, Viktor V.
Graef, Tine
Es-Sayed, Mazen
ORGANIC & BIOMOLECULAR CHEMISTRY, 2012, 10 (31) : 6363 - 6374
[34] Synthesis of Oxindole Analogues, Biological Activity, and In Silico Studies
Lotfy, Gehad
Aziz, Yasmine M. Abdel
Said, Mohamed M.
El Ashry, El Sayed H.
El Tamany, El Sayed H.
Barakat, Assem
Ghabbour, Hazem A.
Yousuf, Sammer
Ul-Haq, Zaheer
Choudhary, M. Iqbal
CHEMISTRYSELECT, 2019, 4 (35): : 10510 - 10516
[35] Synthesis and biological activity of 3-deoxyecdysteroid analogues
Suksamrarn, A
Charoensuk, S
Yingyongnarongkul, BE
TETRAHEDRON, 1996, 52 (32) : 10673 - 10684
[36] Analogues of nociceptin/orphanin FQ: synthesis and biological activity
Zhivkova, Vanya
Naydenova, Emilia
Vezenkov, Lyubomir
Zamfirova, Rositsa
Dobrinova, Yordanka
Todorov, Simeon
Peptides 2004, Proceedings: BRIDGES BETWEEN DISCIPLINES, 2005, : 972 - 973
[37] Synthesis and biological activity of epoxy analogues of 3-dehydroteasterone
Bernardo-Otero, Yamile
Alonso-Becerra, Esther
Guerra-Martinez, Francisco
Martinez-Massanet, Guillermo
Perez-Martinez, Carlos
Coll-Manchado, Francisco
JOURNAL OF CHEMICAL RESEARCH, 2007, (05) : 268 - 271
[38] Design, synthesis and evaluation of biological activity of novel fasudil analogues
Li, Hang
Wang, Donghua
Liu, Shuai
Sun, Changhai
Chen, Meizhu
Wang, Xinran
Chen, Ligong
PHARMAZIE, 2014, 69 (12): : 867 - 873
[39] Design, Synthesis, and Biological Activity of Conformationally Restricted Analogues of Silibinin
Mizuno, Mirei
Mori, Kazunori
Tsuchiya, Keisuke
Takaki, Takashi
Misawa, Takashi
Demizu, Yosuke
Shibanuma, Motoko
Fukuhara, Kiyoshi
ACS OMEGA, 2020, 5 (36): : 23164 - 23174
[40] Opioid peptides: Synthesis and biological activity of new endomorphin analogues
Biondi, Barbara
Giannini, Elisa
Negri, Lucia
Melchiorri, Pietro
Lattanzi, Roberta
Rosso, Federica
Ciocca, Luigi
Rocchi, Raniero
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, 2006, 12 (02) : 145 - 151

← 1 2 3 4 5 →