Cigarette Smoking and Tryptophan Hydroxylase 2 mRNA in the Dorsal Raphe Nucleus in Suicides

被引：2

作者：

Bach, Helene ^{[1
,2
]}

Arango, Victoria ^{[1
,2
]}

Kassir, Suham A. ^{[1
]}

Dwork, Andrew J. ^{[1
,2
]}

Mann, J. John ^{[1
,2
]}

Underwood, Mark D. ^{[1
,2
]}

机构：

[1] New York State Psychiat Inst & Hosp, Dept Mol Imaging & Neuropathol, New York, NY 10032 USA

[2] Columbia Coll Phys & Surg, Dept Psychiat, New York, NY USA

来源：

ARCHIVES OF SUICIDE RESEARCH | 2016年 / 20卷 / 03期

关键词：

human; in situ hybridization; postmortem; serotonin; FUNCTIONAL PROMOTER POLYMORPHISM; IMMOBILIZATION STRESS; DEPRESSED SUICIDES; COGNITIVE FUNCTION; MAJOR DEPRESSION; HUMAN BRAIN; NICOTINE; SEROTONIN; EXPRESSION; VICTIMS;

D O I：

10.1080/13811118.2015.1048398

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Cigarette smoking is associated with suicide and mood disorders and stimulates serotonin release. Tryptophan hydroxylase (TPH2) synthesizes serotonin and is over-expressed in suicides. We determined whether smoking is associated with TPH2 mRNA in suicides and controls. TPH2 mRNA was measured postmortem in the dorsal raphe nucleus (DRN) of controls (N=26, 17 nonsmokers and nine smokers) and suicides (N=23, 5 nonsmokers and 18 smokers). Psychiatric history was obtained by psychological autopsy. TPH2 mRNA was greater in suicide nonsmokers than suicide smokers, control smokers and control nonsmokers (p=0.006). There was more TPH2 mRNA throughout the DRN. Smoking interferes with the TPH2 mRNA increase observed in suicide nonsmokers. The absence of altered TPH2 expression in non-suicide smokers suggests no pharmacological effect of smoking.

引用

页码：451 / 462

页数：12

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