Remote regioselective organocatalytic asymmetric [3+2] cycloaddition of N-2,2,2-trifluoroethyl isatin ketimines with cyclic 2,4-dienones

被引：27

作者：

Zou, Chuncheng ^{[1
,2
]}

Han, Yuanyuan ^{[1
]}

Zeng, Chuikun ^{[1
]}

Zhang, Tony Y. ^{[1
]}

Ye, Jinxing ^{[1
]}

Song, Gonghua ^{[2
]}

机构：

[1] East China Univ Sci & Technol, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, Shanghai 200237, Peoples R China

[2] East China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2020年 / 31卷 / 02期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

Organocatalysis; Spiro oxindole skeleton; 3+2] cycloaddition; Cyclic 2,4-dienones; CF3; group; CATALYZED 1,3-DIPOLAR CYCLOADDITION; SPIROCYCLIC OXINDOLES; CONSTRUCTION; DESIGN; SPIROOXINDOLES; INHIBITORS; DISCOVERY; STRATEGY; CENTERS;

D O I：

10.1016/j.cclet.2019.07.052

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An organocatalytic asymmetric [3 + 2] cycloaddition of trifluoromethyl-containing azomethine ylides with cyclic 2,4-dienones was developed. The process enables efficient incorporation of CF3 groups into functionalized spiro[pyrrolidin-3,2'-oxindoles] in high yields with good to excellent enantio- and diastereoselectivities. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

引用

页码：377 / 380

页数：4

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