Circadian expression of 86-and 84-kDa heat shock proteins in the mouse suprachiasmatic nucleus

被引:4
|
作者
Fukuyama, Tsuyoshi [2 ]
Doi, Masao [1 ,2 ]
Matsuo, Masahiro [1 ,2 ]
Nishinaga, Hiromi [1 ,2 ]
Miyake, Shigeru [2 ]
Okamura, Hitoshi [1 ,2 ]
机构
[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Dept Syst Biol, Sakyo Ku, Kyoto 6068501, Japan
[2] Kobe Univ, Grad Sch Med, Div Mol Brain Sci, Kobe, Hyogo 6500017, Japan
来源
BIOMEDICAL RESEARCH-TOKYO | 2008年 / 29卷 / 02期
关键词
D O I
10.2220/biomedres.29.93
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Circadian rhythm pervades in many aspects of the biological processes including basic cellular functions. Here we examined the circadian gene expression of two forms of 90 kDa heat shock proteins referred to HSP86 and HSP84 in the mouse suprachiasmatic nucleus, the circadian center. In both light-dark, and constant dark conditions, Hsp86 mRNA showed an overt circadian rhythm showing a peak at (subjective) night and a trough at (subjective) day. Hsp84 mRNA also showed the similar expression profile, but the amplitude was weaker. These results indicate that gene expression of molecular chaperone such as Hsp86 and Hsp84 are regulated by the circadian clock.
引用
收藏
页码:93 / 98
页数:6
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