Synthesis of some new bioactive 1-N-subtituted 3,5-diaryl-2-pyrazolines

被引:0
|
作者
Khan, Sadaf Sadiq [1 ]
Hasan, Aurangzeb [1 ]
机构
[1] Quaid i Azam Univ, Dept Chem, Islamabad 45320, Pakistan
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中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A group of four series (A-D) of 22 new bioactive 1-N-acid substituted 3, 5-diphenyl-2-pyrazolines were synthesized by cyclization of variably substituted chalcones and simple or substituted phenyl hydrazine and / or semicarbazide, using acetic acid as a solvent. The chemical structure of the compounds was characterized by FTIR, (HNMR)-H-1, and EIMS spectroscopy and chemical analyses. The antifungal and antibacterial activities of these compounds were evaluated by agar tube dilution method and agar well diffusion method respectively.
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页码:131 / 138
页数:8
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