The Effects of Remifentanil on Hemodynamic Response Attenuation After Electroconvulsive Therapy Under Sevoflurane Anesthesia

被引:8
|
作者
Erdil, Feray [1 ]
Ozgul, Ulku [1 ]
Sanli, Mukadder [1 ]
Kayhan, Gulay [1 ]
Colak, Cemil [2 ]
Durmus, Mahmut [1 ]
机构
[1] Inonu Univ, Fac Med, Dept Anesthesiol & Reanimat, Malatya, Turkey
[2] Inonu Univ, Fac Med, Dept Biostat, Malatya, Turkey
关键词
electroconvulsive therapy; remifentanil; major depression; sevoflurane; hemodynamic; SEIZURE DURATION; PROPOFOL ANESTHESIA; DOUBLE-BLIND; INDUCTION; PLACEBO; TRIAL; RISK; ECT;
D O I
10.1097/YCT.0000000000000411
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Purpose We evaluated the effects of a single loading dose of remifentanil (1 g/kg) administered as an adjunct to sevoflurane, on the duration of seizure activity, recovery times, and hemodynamic profiles, during electroconvulsive therapy. Methods The patients were randomly allocated to receive sevoflurane-saline (Group SS) or sevoflurane-remifentanil (Group SR). Sevoflurane (8%) was initiated for anesthesia induction in both groups until loss of consciousness was achieved. Remifentanil was then administered to Group SR via a 1-g/kg intravenous bolus. Patients in Group SS received saline in the same manner. Mean arterial pressure (MAP) and heart rate (HR) were recorded before anesthetic induction (T1), at the loss of consciousness (T2), and at 0, 1, 3, and 10 minutes after the electrical stimuli were completed (T3, T4, T5, and T6, respectively). Results Compared with the baseline values, HR increased significantly in Group SS at times T2 and T4 to T6 and decreased significantly in Group SR at time T2. When the groups were compared, we found that HR decreased significantly in Group SR at T2 and T4 to T6. Compared with baseline, MAP increased in Group SS between T3 and T6, and MAP decreased in Group SR at T2 and increased at T3 to T4. Mean arterial pressure decreased to a greater extent in Group SR than in Group SS during the T2 to T6 period. There were no group differences in seizure duration or recovery time. Conclusions The addition of 1-g/kg remifentanil to anesthetic induction with sevoflurane attenuated the acute hemodynamic response to electroconvulsive therapy under sevoflurane anesthesia without adversely affecting the duration of seizure activity or the recovery profile.
引用
收藏
页码:264 / 267
页数:4
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