Toll Signaling in Flies and Mammals: Two Sorts of MyD88

被引:7
|
作者
Goto, Akira [1 ]
Imler, Jean-Luc [1 ,2 ]
机构
[1] CNRS, UPR9022, Inst Biol Mol & Cellulaire, F-67084 Strasbourg, France
[2] Univ Strasbourg, Fac Sci Vie, F-67083 Strasbourg, France
关键词
DROSOPHILA EMBRYO; PATHWAY;
D O I
10.1016/j.immuni.2012.04.001
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The mammalian MyD88 signaling molecule participates in Toll receptor signaling within the cytoplasm. In this issue of Immunity, Marek and Kagan (2012) report that Drosophila (d)MyD88 acts instead at the plasma membrane to sort the signaling adaptor Tube.
引用
收藏
页码:555 / 557
页数:3
相关论文
共 50 条
  • [21] Two adaptor molecules of MyD88 and TRAF6 in Apostichopus japonicus Toll signaling cascade: Molecular cloning and expression analysis
    Lu Yali
    Li Chenghua
    Zhang Peng
    Shao Yina
    Su Xiurong
    Li Ye
    Li Taiwu
    DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2013, 41 (04): : 498 - 504
  • [22] Distinct effects of rage & MYD88 signaling in massive hepatectomy
    Zeng, Shan
    Dun, Hao
    Ippagunta, Nikalesh
    Rosaria, Rosa H.
    Schmidt, Ann Marie
    Emond, Jean C.
    HEPATOLOGY, 2007, 46 (04) : 273A - 273A
  • [23] The role of MyD88 signaling in heterosubtypic influenza A virus infections
    Madera, Rachel F.
    Libraty, Daniel H.
    VIRUS RESEARCH, 2013, 171 (01) : 216 - 221
  • [24] Discovering differential activation machinery of the Toll-like receptor 4 signaling pathways in MyD88 knockouts
    Selvarajoo, K
    FEBS LETTERS, 2006, 580 (05): : 1457 - 1464
  • [25] Disruption of MyD88 signaling suppresses hemophagocytic lymphohistiocytosis in mice
    Krebs, Philippe
    Crozat, Karine
    Popkin, Daniel
    Oldstone, Michael B.
    Beutler, Bruce
    BLOOD, 2011, 117 (24) : 6582 - 6588
  • [26] Functions of MyD88 signaling in a mouse model of atopic dermatitis
    Didovic, S.
    Opitz, F.
    Holzmann, B.
    Foerster, I.
    Weighardt, H.
    EXPERIMENTAL DERMATOLOGY, 2014, 23 (03) : E29 - E29
  • [27] Role for MyD88 signaling in murine gammaherpesvirus 68 latency
    Gargano, Lisa M.
    Moser, Janice M.
    Speck, Samuel H.
    JOURNAL OF VIROLOGY, 2008, 82 (08) : 3853 - 3863
  • [28] MyD88 Signaling in the Intestine: Dr Jekyll and Mr Hyde?
    Jobin, Christian
    GASTROENTEROLOGY, 2010, 139 (02) : 383 - 386
  • [29] Mechanism of TOLL/IL-1 receptor domain dimerization and signaling revealed by a crystal structure of the MYD88
    Snyder, Greg A.
    Jiang, Jiansheng
    Xiao, Tsan
    CYTOKINE, 2008, 43 (03) : 291 - 291
  • [30] SYK is activated by mutated MYD88 and drives pro-survival signaling in MYD88 driven B-cell lymphomas
    Munshi, Manit
    Liu, Xia
    Chen, Jiaji G.
    Xu, Lian
    Tsakmaklis, Nickolas
    Demos, Maria G.
    Kofides, Amanda
    Guerrera, Maria Luisa
    Jimenez, Cristina
    Chan, Gloria G.
    Hunter, Zachary R.
    Palomba, M. Lia
    Argyropoulos, Kimon, V
    Meid, Kirsten
    Keezer, Andrew
    Gustine, Joshua
    Dubeau, Toni
    Castillo, Jorge J.
    Patterson, Christopher J.
    Wang, Jinhua
    Buhrlage, Sara J.
    Gray, Nathanael S.
    Treon, Steven P.
    Yang, Guang
    BLOOD CANCER JOURNAL, 2020, 10 (01)