Synthesis and antimicrobial activity of 3,4-bis(arylthio)maleimides

被引：10
|
作者：
Panov, Alexey A. [1 ]
Lavrenov, Sergey N. [1 ]
Simonov, Alexander Y. [1 ]
Mirchink, Elena P. [1 ]
Isakova, Elena B. [1 ]
Trenin, Alexey S. [1 ]
机构：
[1] Gause Inst New Antibiot, 11 B Pirogovskaya St, Moscow 119021, Russia
来源：
JOURNAL OF ANTIBIOTICS | 2019年 / 72卷 / 02期
基金：
俄罗斯科学基金会;
关键词：
TEICOPLANIN PSEUDOAGLYCON DERIVATIVES; MALEIMIDES; INHIBITORS;
D O I：
10.1038/s41429-018-0122-3
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A series of 3,4-bis(arylthio)maleimides were synthesized and their antimicrobial activity was evaluated against Gram-positive and Gram-negative bacteria, including multidrug resistant (MDR) strains and some fungi. Most compounds turned out to be highly active, activity being dependent on substituents on phenyl rings.
引用
收藏
页码：122 / 124
页数：3
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