Leptin and the Central Nervous System Control of Glucose Metabolism

被引：228
|
作者：
Morton, Gregory J. [1 ]
Schwartz, Michael W. [1 ]
机构：
[1] Univ Washington, Dept Med, Diabet & Obes Ctr Excellence, Seattle, WA 98195 USA
来源：
PHYSIOLOGICAL REVIEWS | 2011年 / 91卷 / 02期
关键词：
INSULIN-RECEPTOR SUBSTRATE-2; STEAROYL-COA DESATURASE-1; HYPOTHALAMIC ARCUATE NUCLEUS; MESSENGER-RNA EXPRESSION; ATP CHANNEL ACTIVATION; DIET-INDUCED OBESITY; Y GENE-EXPRESSION; CAUDAL BRAIN-STEM; FOOD-INTAKE; BODY-WEIGHT;
D O I：
10.1152/physrev.00007.2010
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Morton GJ, Schwartz MW. Leptin and the Central Nervous System Control of Glucose Metabolism. Physiol Rev 91: 389-411, 2011; doi:10.1152/physrev.00007.2010.-The regulation of body fat stores and blood glucose levels is critical for survival. This review highlights growing evidence that leptin action in the central nervous system plays a key role in both processes. Investigation into underlying mechanisms has begun to clarify the physiological role of leptin in the control of glucose metabolism and raises interesting new possibilities for the treatment of diabetes and related disorders.
引用
收藏
页码：389 / 411
页数：23
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