Influence of Drug Load on the Printability and Solid-State Properties of 3D-Printed Naproxen-Based Amorphous Solid Dispersion

被引:16
|
作者
Kissi, Eric Ofosu [1 ]
Nilsson, Robin [2 ]
Nogueira, Liebert Parreiras [3 ]
Larsson, Anette [2 ]
Tho, Ingunn [1 ]
机构
[1] Univ Oslo, Dept Pharm, POB 1068 Blindern, N-0316 Oslo, Norway
[2] Chalmers Univ Technol, Dept Chem & Chem Engn, Kemivagen 10, S-41296 Gothenburg, Sweden
[3] Univ Oslo, Inst Clin Dent, Dept Biomat, POB 1109 Blindern, N-0317 Oslo, Norway
来源
MOLECULES | 2021年 / 26卷 / 15期
关键词
3D printing; additive manufacturing; fused deposition modelling; hot-melt extrusion; X-ray computed microtomography; glass solution; HOT-MELT EXTRUSION; POLYMER SOLUBILITY; DELIVERY; CRYSTALLIZATION; TEMPERATURE; PERFORMANCE; SYSTEMS;
D O I
10.3390/molecules26154492
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Fused deposition modelling-based 3D printing of pharmaceutical products is facing challenges like brittleness and printability of the drug-loaded hot-melt extruded filament feedstock and stabilization of the solid-state form of the drug in the final product. The aim of this study was to investigate the influence of the drug load on printability and physical stability. The poor glass former naproxen (NAP) was hot-melt extruded with Kollidon(R) VA 64 at 10-30% w/w drug load. The extrudates (filaments) were characterised using differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA), and thermogravimetric analysis (TGA). It was confirmed that an amorphous solid dispersion was formed. A temperature profile was developed based on the results from TGA, DSC, and DMA and temperatures used for 3D printing were selected from the profile. The 3D-printed tablets were characterised using DSC, X-ray computer microtomography (X mu CT), and X-ray powder diffraction (XRPD). From the DSC and XRPD analysis, it was found that the drug in the 3D-printed tablets (20 and 30% NAP) was amorphous and remained amorphous after 23 weeks of storage (room temperature (RT), 37% relative humidity (RH)). This shows that adjusting the drug ratio can modulate the brittleness and improve printability without compromising the physical stability of the amorphous solid dispersion.
引用
收藏
页数:15
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