SmI2-Mediated Carbonyl-Alkene Couplings for the Synthesis of Small Carbocyclic Rings

被引：55
|
作者：
Harb, Hassan Y. [1 ]
Procter, David J. [1 ]
机构：
[1] Univ Manchester, Sch Chem, Manchester M13 9PL, Lancs, England
来源：
SYNLETT | 2012年 / 23卷 / 01期
基金：
英国工程与自然科学研究理事会;
关键词：
samarium diiodide; radical reactions; cyclization; small rings; natural product synthesis; SAMARIUM(II)-MEDIATED 4-EXO-TRIG CYCLIZATION; SAMARIUM DIIODIDE; 3-EXO-TRIG CYCLIZATION; STEREOSELECTIVE CYCLIZATION; STEREOCONTROLLED APPROACH; UNSATURATED ALDEHYDES; SELECTIVE REDUCTIONS; CYCLIC 1,3-DIESTERS; PROTON DONORS; SMI2;
D O I：
10.1055/s-0031-1290093
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The electron transfer reducing agent samarium diiodide (SmI2) mediates reductive carbonyl-alkene couplings to give small carbocyclic rings with high diastereocontrol. The substrate scope and mechanism of the reactions is discussed. The application of these versatile reactions in target synthesis is also described.
引用
收藏
页码：6 / 20
页数：15
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