Regulation of CD44 expression by tumor necrosis factor-α and its potential role in breast cancer cell migration

被引：22
|
作者：
Li, Jun [1 ]
Zha, Xiao-Ming [3 ]
Wang, Rong [1 ]
Li, Xiao-Dong [1 ,2 ]
Xu, Bei [1 ]
Xu, Yan-Jie [1 ]
Yin, Yong-Mei [1 ]
机构：
[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Med Oncol, Nanjing 210029, Jiangsu, Peoples R China
[2] Soochow Univ, Affiliated Hosp 3, Dept Oncol, Changzhou, Peoples R China
[3] Nanjing Med Univ, Affiliated Hosp 1, Dept Breast Surg, Nanjing 210029, Jiangsu, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2012年 / 66卷 / 02期
关键词：
Breast cancer; TNF-alpha; CD44; Migration; MAPK; COLORECTAL-CANCER; SPLICE VARIANTS; MAPK PATHWAY; CARCINOMA; PROGRESSION; METASTASIS; INVASION; ACTIVATION; CYTOKINES; RECEPTOR;
D O I：
10.1016/j.biopha.2011.11.021
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
CD44 molecule plays critical role in distant malignant metastasis. It is expressed in standard form (CD44s) or variant form (CD44v). Tumor necrosis factor-alpha (TNF-alpha) is highly expressed in the cancer microenvironment. TNF-alpha was reported to modulate CD44 expression in several kinds of cancer. However, little is known about pathological role of TNF-alpha in breast cancer (BC) cells. In the current investigation, we investigated the effect of TNF-alpha on BC cells (MCF-7 and MDA-MB-231) viability, CD44 expression, and in vitro migration. We found that TNF-alpha down-regulated CD44s expression, up-regulated CD44v3 and CD44v6 expression through JNK pathway in MCF-7 cells. In MDA-MB-231 cells, TNF-alpha up-regulated CD44s, CD44v3 and CD44v6 expression via p38 pathway. These data indicate important role of CD44 molecule in BC pathology. (c) 2012 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：144 / 150
页数：7
相关论文
共 50 条
  • [41] Regulation of tissue factor dependent procoagulant properties by CD44: Implication for metastasis of breast tumor cells.
    Villard, Amelie V.
    Genna, Anthony
    Gilles, Christine
    CANCER RESEARCH, 2022, 82 (12)
  • [42] Tumor Necrosis Factor-α, a Regulator and Therapeutic Agent on Breast Cancer
    Liu, Dongwu
    Wang, Xiaoqian
    Chen, Zhiwei
    CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2016, 17 (06) : 486 - 494
  • [43] Regulation of CD44 expression and focal adhesion by Golgi phosphatidylinositol 4-phosphate in breast cancer
    Ijuin, Takeshi
    Takeuchi, Yukiko
    Shimono, Yohei
    Fukumoto, Miki
    Tokuda, Emi
    Takenawa, Tadaomi
    CANCER SCIENCE, 2016, 107 (07): : 981 - 990
  • [44] Cancer stem cell marker, CD44 expression in Indian breast carcinoma patients and its association with the molecular subtypes of breast carcinoma
    Singh, K.
    Jain, M.
    Agarwal, K.
    Pathania, O.
    BREAST, 2017, 32 : S105 - S105
  • [45] DOWN-REGULATION BY TUMOR-NECROSIS-FACTOR-ALPHA OF NEUTROPHIL CELL-SURFACE EXPRESSION OF THE SIALOPHORIN CD43 AND THE HYALURONATE RECEPTOR CD44 THROUGH A PROTEOLYTIC MECHANISM
    CAMPANERO, MR
    PULIDO, R
    ALONSO, JL
    PIVEL, JP
    PIMENTELMUINOS, FX
    FRESNO, M
    SANCHEZMADRID, F
    EUROPEAN JOURNAL OF IMMUNOLOGY, 1991, 21 (12) : 3045 - 3048
  • [46] Biphasic Dependence of Glioma Survival and Cell Migration on CD44 Expression Level
    Klank, Rebecca L.
    Grunke, Stacy A. Decker
    Bangasser, Benjamin L.
    Forster, Colleen L.
    Price, Matthew A.
    Odde, Thomas J.
    SantaCruz, Karen S.
    Rosenfeld, Steven S.
    Canoll, Peter
    Turley, Eva A.
    McCarthy, James B.
    Ohlfest, John R.
    Odde, David J.
    CELL REPORTS, 2017, 18 (01): : 23 - 31
  • [47] Profile of CD44 expression in prostate carcinoma: A potential marker for tumor aggressiveness
    Gelb, A
    Gakunga, P
    Shuster, S
    Stern, R
    LABORATORY INVESTIGATION, 1997, 76 (01) : 434 - 434
  • [48] Interaction of CD44 with different forms of hyaluronic acid. Its role in adhesion and migration of tumor cells
    Alaniz, L
    Cabrera, PV
    Blanco, G
    Ernst, G
    Rimoldi, G
    Alvarez, E
    Hajos, SE
    CELL COMMUNICATION AND ADHESION, 2002, 9 (03): : 117 - 130
  • [49] Tumor necrosis factor-α expression in human uterine leiomyoma and its down-regulation by progesterone
    Kurachi, O
    Matsuo, H
    Samoto, T
    Maruo, T
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (05): : 2275 - 2280
  • [50] CD44 intracytoplasmic domain(CD44-ICD)-dependent gene regulation in breast cancer cells
    Grinnage, D. A.
    Miletti, K. E.
    MOLECULAR BIOLOGY OF THE CELL, 2013, 24
12345