Regulation of CD44 expression by tumor necrosis factor-α and its potential role in breast cancer cell migration

被引：22

作者：

Li, Jun ^{[1
]}

Zha, Xiao-Ming ^{[3
]}

Wang, Rong ^{[1
]}

Li, Xiao-Dong ^{[1
,2
]}

Xu, Bei ^{[1
]}

Xu, Yan-Jie ^{[1
]}

Yin, Yong-Mei ^{[1
]}

机构：

[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Med Oncol, Nanjing 210029, Jiangsu, Peoples R China

[2] Soochow Univ, Affiliated Hosp 3, Dept Oncol, Changzhou, Peoples R China

[3] Nanjing Med Univ, Affiliated Hosp 1, Dept Breast Surg, Nanjing 210029, Jiangsu, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2012年 / 66卷 / 02期

关键词：

Breast cancer; TNF-alpha; CD44; Migration; MAPK; COLORECTAL-CANCER; SPLICE VARIANTS; MAPK PATHWAY; CARCINOMA; PROGRESSION; METASTASIS; INVASION; ACTIVATION; CYTOKINES; RECEPTOR;

D O I：

10.1016/j.biopha.2011.11.021

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

CD44 molecule plays critical role in distant malignant metastasis. It is expressed in standard form (CD44s) or variant form (CD44v). Tumor necrosis factor-alpha (TNF-alpha) is highly expressed in the cancer microenvironment. TNF-alpha was reported to modulate CD44 expression in several kinds of cancer. However, little is known about pathological role of TNF-alpha in breast cancer (BC) cells. In the current investigation, we investigated the effect of TNF-alpha on BC cells (MCF-7 and MDA-MB-231) viability, CD44 expression, and in vitro migration. We found that TNF-alpha down-regulated CD44s expression, up-regulated CD44v3 and CD44v6 expression through JNK pathway in MCF-7 cells. In MDA-MB-231 cells, TNF-alpha up-regulated CD44s, CD44v3 and CD44v6 expression via p38 pathway. These data indicate important role of CD44 molecule in BC pathology. (c) 2012 Elsevier Masson SAS. All rights reserved.

引用

页码：144 / 150

页数：7

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