Sequential experimental design for model discrimination - Taking into account the posterior covariance matrix of differences between model predictions

Techniques for experimental design of experiments for model discrimination constitute important tools for scientists and engineers, as analyzed phenomena can very often be described fairly well by different mathematical models. As interpretation and use of available experimental data depend on the model structure, techniques for design of experiments for selection of the best model are of fundamental importance. Besides, experiments must often be designed for estimation of model parameters and reduction of variances of model predictions (or parameter estimates). These two classes of experimental design techniques generally lead to different experimental designs, although model discrimination and reduction of variances of parameter estimates are closely related to each other. In this work the posterior covariance matrix of difference between model predictions is taken into account during the design for model discrimination for the first time. The obtained results show that the model discrimination power becomes much higher when the posterior covariance matrix of difference between model predictions are considered during the experimental design, increasing the capability of model discrimination and simultaneously leading to improved parameter estimates. (c) 2008 Elsevier Ltd. All rights reserved.