Inflammatory breast cancer outcomes by breast cancer subtype: a population-based study

被引：15
|
作者：
Wu, San-Gang [1 ]
Zhang, Wen-Wen [2 ]
Wang, Jun [1 ]
Dong, Yong [3 ]
Sun, Jia-Yuan [2 ]
Chen, Yong-Xiong [4 ]
He, Zhen-Yu [2 ]
机构：
[1] Xiamen Univ, Affiliated Hosp 1, Xiamen Canc Hosp, Dept Radiat Oncol, Xiamen 361003, Peoples R China
[2] Sun Yat Sen Univ, Collaborat Innovat Ctr Canc Med, State Key Lab Oncol South China, Dept Radiat Oncol,Canc Ctr, Guangzhou 510060, Guangdong, Peoples R China
[3] 3rd Peoples Hosp Dongguan City, Dept Oncol, Dongguan 523326, Peoples R China
[4] Xiamen Univ, Coll Med, Eye Inst, Fujian Prov Key Lab Ophthalmol & Visual Sci, Xiamen 361005, Peoples R China
来源：
FUTURE ONCOLOGY | 2019年 / 15卷 / 05期
关键词：
inflammatory breast cancer; prognosis; SEER; subtype; survival; treatment; MOLECULAR SUBTYPES; SURVIVAL; RADIOTHERAPY; THERAPY; TRENDS; EPIDEMIOLOGY; SURVEILLANCE; MANAGEMENT; CARCINOMA; DIAGNOSIS;
D O I：
10.2217/fon-2018-0677
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: To assess the outcomes of breast cancer subtype in inflammatory breast cancer (IBC). Methods: We retrospectively assessed IBC patients from the SEER program. Results: We identified 626 patients, including 230 (36.7%),100 (17.6%), 113 (18.1%), and 173 (27.6%) patients with HoR+/HER2-, HoR+/HER2+, HoR-/HER2+, and HoR-/HER2- subtype disease, respectively. Multivariate analysis demonstrated that, using HoR+/HER2- subtype as reference, patients with HoR+/HER2+ subtype had better breast cancer-specific survival (BCSS) and overall survival (OS), and patients with HoR-/HER2- subtype had worse BCSS and OS, while BCSS and OS were comparable for HoR-/HER2+ subtype. Similar trends were observed in patients who received surgery, radiotherapy, chemotherapy or trimodality therapy. Conclusion: Breast cancer subtype is clinically useful for predicting survival outcome in IBC. The HoR+/HER2- subtype shows poorer survival outcome than HoR+/HER2+ subtype.
引用
收藏
页码：507 / 516
页数：10
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