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- [36] 17β-estradiol induces IL-1α gene expression in rheumatoid fibroblast-like synovial cells through estrogen receptor α (ERα) and augmentation of transcriptional activity of Sp1 by dissociating histone deacetylase 2 from ERα JOURNAL OF IMMUNOLOGY, 2007, 178 (05): : 3059 - 3066