A new isocoumarin from mangrove endophytic fungus (No. dz17) on the South China Sea coast

被引：22
|
作者：
Huang, Zhongjing [1 ]
Shao, Changlun [1 ]
Chen, Yiguang [1 ]
She, Zhigang [1 ]
Lin, Yongcheng [1 ]
Zhou, Shining [2 ]
机构：
[1] Zhongshan Univ, Coll Chem & Chem Engn, Guangzhou 510275, Peoples R China
[2] Zhongshan Univ, Coll Life Sci, Guangzhou 510275, Peoples R China
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2007年 / 43卷 / 06期
基金：
中国国家自然科学基金;
关键词：
mangrove endophytic fungus; isocoumarin; metabolites;
D O I：
10.1007/s10600-007-0221-z
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new isocoumarin, 3,4-dihydro-6-methoxy-8-hydroxy-3,4,5-trimethylisocoumarin-7-carboxylic acid methyl ester (1), together with three known compounds, 3,4-dihydro-4,8-dihydroxy-3,5-dimethylisocoumarin (2), 3,4-dihydro-8-hydroxy-3-methylisocoumarin-5-carboxylic acid (3), and Entinclole SB (4) were isolated from the mangrove endophytic fungus (No. dz17). The structure of the compound 1 was elucidated by analysis of spectroscopic data. Primary bioassays showed that 1 exhibited weak cytotoxicity against Hep-2 and HepG2 cells.
引用
收藏
页码：655 / 658
页数：4
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