Placebo-controlled trials in pediatric urology: A cautionary view from an ethical perspective

被引：9

作者：

Braga, Luis H. P. ^{[1
]}

Bagli, Darius J. ^{[2
]}

Lorenzo, Armando J. ^{[2
]}

机构：

[1] McMaster Univ, Div Pediat Urol, McMasters Children Hosp, Hamilton, ON L8N 3Z5, Canada

[2] Univ Toronto, Hosp Sick Children, Toronto, ON M5S 1A1, Canada

来源：

JOURNAL OF PEDIATRIC UROLOGY | 2010年 / 6卷 / 05期

关键词：

Ethics; Children; Consent form; Placebo; Randomized clinical trials; Narrative review; URINARY-TRACT-INFECTION; ANTIBIOTIC-PROPHYLAXIS; VESICOURETERAL REFLUX; POSTNATAL MANAGEMENT; DOUBLE-BLIND; CHILDREN; INFANTS; HYDRONEPHROSIS; PREVENTION; ENURESIS;

D O I：

10.1016/j.jpurol.2010.02.208

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The ethical dispute regarding placebo-controlled trials is discussed in this review. Important issues, such as clinical equipoise, fiduciary obligation and middle ground theory, are examined in the context of pediatric urology clinical research. After reviewing the literature, the authors summarize specific indications for placebo-controlled trials in pediatric urology, and emphasize that physicians have ethical and moral obligations to patients, in the sense that one should carefully plan and conduct such trials in order to gain clinically important information without exposing children to undue risks. (C) 2010 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.

引用

页码：435 / 442

页数：8

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