Merits of secretion of heterologous proteins from industrial microorganisms

被引：21
|
作者：
Quax, WJ [1 ]
机构：
[1] LEIDEN UNIV, LEIDEN INST CHEM, GORLAEUS LABS, NL-2300 RA LEIDEN, NETHERLANDS
来源：
FOLIA MICROBIOLOGICA | 1997年 / 42卷 / 02期
关键词：
D O I：
10.1007/BF02898715
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The heterologous expression of proteins is without doubt one of the most fascinating applications of the recombinant DNA technique. Despite clear successes many attemps to produce a certain protein in a heterologous host cell have met with technical difficulties. Secretion from cells has been used as a solution to overcome the intracellular formation of inactive protein. Microorganisms with a history of use in the fermentation industry exhibit clear advantages over the frequently used Escherichia coli as host cells for secreted products. Interleukin-3, chymosin and phytase are examples of commercial products that are produced efficiently with the aid of industrial microorganisms.
引用
收藏
页码：99 / 103
页数：5
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