Ofatumumab in the treatment of non-Hodgkin's lymphomas

被引：10
|
作者：
Karlin, Lionel [1 ]
Coiffier, Bertrand [1 ]
机构：
[1] Hosp Civils Lyon, Ctr Hosp Lyon Sud, Dept Hematol, F-69495 Pierre Benite, France
来源：
EXPERT OPINION ON BIOLOGICAL THERAPY | 2015年 / 15卷 / 07期
关键词：
diffuse large B-cell lymphoma; follicular lymphoma; ofatumumab; B-CELL LYMPHOMA; CHRONIC LYMPHOCYTIC-LEUKEMIA; REFRACTORY FOLLICULAR LYMPHOMA; ANTI-CD20; MONOCLONAL-ANTIBODY; PHASE-II TRIAL; PLUS RITUXIMAB; TARGETING BTK; CHEMOTHERAPY; MULTICENTER; COMBINATION;
D O I：
10.1517/14712598.2015.1055241
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Introduction: Ofatumumab is a second-generation humanized monoclonal antibody targeting CD20 registered for the treatment of patients with relapsing/refractory chronic lymphocytic leukemia. This review will describe the activity of ofatumumab in patients with CD20 B-cell lymphomas. Areas covered: A review of all manuscript published on ofatumumab activity in B-cell lymphomas is presented with conclusions on the future use of this antibody in these patients. Expert opinion: Ofatumumab activity is low in indolent or aggressive B-cell lymphomas. The future of this drug is challenged by new monoclonal antibodies and new targeted drugs.
引用
收藏
页码：1085 / 1091
页数：7
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