Synthetic studies in 6H-[1,2,4]-triazino [3,4-b][1,3,4] thiadiazines

被引：0

作者：

Heravi, MM ^{[1
]}

Nooshabadi, MA

Khosrofar, P

Oskooie, HA

Beheshtiha, YS

Saffarzadeh, S

机构：

[1] Chem & Chem Engn Res Ctr Iran, Tehran, Iran

[2] Ferdowsi Univ Mashhad IR Iran, Sch Sci, Dept Chem, Mashhad, Iran

[3] Alzahra Univ, Dept Chem, Tehran, Iran

来源：

INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 1998年 / 8卷 / 02期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4-Amino-6-methyl-1,2,4-triazine-3-(2H) thioxo-5-one 1 was condensed with chloroacetyl chloride to yield the corresponding 4-chloromethylamide 2. Treatment of 2 with sodium methoxide afforded the bicyclic product, 3-methyl-6H, [1,2,4] triazino [3,4-b] [1,3,4] thiadiazine-5,7 dione 3. Condensation of 1 with allyl bromide afforded 3-allylthio-4-amino-6-methyl-1,2,4-triazin-5-one 4. The latter was treated with excess of bromine to afford 7-bromomethyl 3-methyl-4-oxo-6H- [1,2,4] triazino [3,4-b] [1,3,4] thiadiazine 6 which was reacted with different nucleophiles such as morpholine and diethylamine to give 7 and 8 respectively.

引用

页码：167 / 170

页数：4

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