Synthetic studies in 6H-[1,2,4]-triazino [3,4-b][1,3,4] thiadiazines

被引：0
|
作者：
Heravi, MM [1 ]
Nooshabadi, MA
Khosrofar, P
Oskooie, HA
Beheshtiha, YS
Saffarzadeh, S
机构：
[1] Chem & Chem Engn Res Ctr Iran, Tehran, Iran
[2] Ferdowsi Univ Mashhad IR Iran, Sch Sci, Dept Chem, Mashhad, Iran
[3] Alzahra Univ, Dept Chem, Tehran, Iran
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 1998年 / 8卷 / 02期
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
4-Amino-6-methyl-1,2,4-triazine-3-(2H) thioxo-5-one 1 was condensed with chloroacetyl chloride to yield the corresponding 4-chloromethylamide 2. Treatment of 2 with sodium methoxide afforded the bicyclic product, 3-methyl-6H, [1,2,4] triazino [3,4-b] [1,3,4] thiadiazine-5,7 dione 3. Condensation of 1 with allyl bromide afforded 3-allylthio-4-amino-6-methyl-1,2,4-triazin-5-one 4. The latter was treated with excess of bromine to afford 7-bromomethyl 3-methyl-4-oxo-6H- [1,2,4] triazino [3,4-b] [1,3,4] thiadiazine 6 which was reacted with different nucleophiles such as morpholine and diethylamine to give 7 and 8 respectively.
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页码：167 / 170
页数：4
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