On-label and off-label drug use in the treatment of endometriosis

被引：40

作者：

Quaas, Alexander M. ^{[1
]}

Weedin, Elizabeth A. ^{[1
]}

Hansen, Karl R. ^{[1
]}

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Dept Obstet & Gynecol, Sect Reprod Endocrinol & Infertil, Oklahoma City, OK 73190 USA

来源：

FERTILITY AND STERILITY | 2015年 / 103卷 / 03期

关键词：

Endometriosis; off-label treatment; CHRONIC PELVIC PAIN; DOUBLE-BLIND; LEUPROLIDE ACETATE; SYMPTOMATIC ENDOMETRIOSIS; PENTOXIFYLLINE THERAPY; CONSERVATIVE SURGERY; LAPAROSCOPIC SURGERY; MEDICAL-MANAGEMENT; CONTRACEPTIVE PILL; VALPROIC ACID;

D O I：

10.1016/j.fertnstert.2015.01.006

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Endometriosis, characterized by the presence of endometrial glands and stroma in extrauterine locations, is a significant cause of pelvic pain and infertility, as well as a major health care burden. Although Food and Drug Administration (FDA)-approved treatments are available, the use of "off-label'' medications for endometriosis is widespread. In this review, we provide an overview of the current FDA-approved treatments, followed by a detailed review of the major "off-label'' treatments being used in the United States and worldwide, including efficacy, side effects, drug interactions, contraindications, and anomaly risks. ((c) 2015 by American Society for Reproductive Medicine.)

引用

页码：612 / 625

页数：14

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