Long-wavelength fluorescent boronate probes for the detection and intracellular imaging of peroxynitrite

被引：110
|
作者：
Sedgwick, Adam C. [1 ]
Han, Hai-Hao [2 ,3 ]
Gardiner, Jordan E. [1 ]
Bull, Steven D. [1 ]
He, Xiao-Peng [2 ,3 ]
James, Tony D. [1 ]
机构：
[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England
[2] East China Univ Sci & Technol, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China
[3] East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, 130 Meilong Rd, Shanghai 200237, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 95期
基金：
英国工程与自然科学研究理事会; 中国国家自然科学基金;
关键词：
DUAL-CHANNEL PROBE; LIVING CELLS; NITRIC-OXIDE; IN-VIVO; HYDROGEN-PEROXIDE; OXIDATIVE STRESS; FAR-RED; CHROMOPHORES; SUPEROXIDE; NITRATION;
D O I：
10.1039/c7cc07845e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Two boronate fluorescent probes have been developed for the detection of peroxynitrite (TCFB1 and TCFB2). TCFB1 was shown to have a low sensitvity towards peroxynitrite and have a poor solubility in aqueous solution whereas TCFB2 demonstrated high sensitivity towards peroxynitrite and mitochondria localisation with the ability to detect exogenous and endogenous peroxynitrite in live cells (Hep-G2, RAW 264.7, HeLa and A459).
引用
收藏
页码：12822 / 12825
页数：4
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