Long-wavelength fluorescent boronate probes for the detection and intracellular imaging of peroxynitrite

被引：110

作者：

Sedgwick, Adam C. ^{[1
]}

Han, Hai-Hao ^{[2
,3
]}

Gardiner, Jordan E. ^{[1
]}

Bull, Steven D. ^{[1
]}

He, Xiao-Peng ^{[2
,3
]}

James, Tony D. ^{[1
]}

机构：

[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England

[2] East China Univ Sci & Technol, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China

[3] East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, 130 Meilong Rd, Shanghai 200237, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 95期

基金：

英国工程与自然科学研究理事会; 中国国家自然科学基金;

关键词：

DUAL-CHANNEL PROBE; LIVING CELLS; NITRIC-OXIDE; IN-VIVO; HYDROGEN-PEROXIDE; OXIDATIVE STRESS; FAR-RED; CHROMOPHORES; SUPEROXIDE; NITRATION;

D O I：

10.1039/c7cc07845e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two boronate fluorescent probes have been developed for the detection of peroxynitrite (TCFB1 and TCFB2). TCFB1 was shown to have a low sensitvity towards peroxynitrite and have a poor solubility in aqueous solution whereas TCFB2 demonstrated high sensitivity towards peroxynitrite and mitochondria localisation with the ability to detect exogenous and endogenous peroxynitrite in live cells (Hep-G2, RAW 264.7, HeLa and A459).

引用

页码：12822 / 12825

页数：4

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