Cytotoxic copper (II) mixed ligand complexes: Crystal structure and DNA cleavage activity

被引：39
|
作者：
Manikandamathavan, Verasuntharam M. [1 ]
Parameswari, Royapuram P. [3 ]
Weyhermueller, Thomas [2 ]
Vasanthi, Hannah R. [3 ]
Nair, Balachandran Unni [1 ]
机构：
[1] Cent Leather Res Inst, Chem Lab, Madras 600020, Tamil Nadu, India
[2] Max Planck Inst Bioanorgan Chem, D-45413 Mulheim, Germany
[3] Sri Ramachandra Univ, Herbal & Indian Med Res Lab, Dept Biochem, Madras 600116, Tamil Nadu, India
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2011年 / 46卷 / 09期
关键词：
Copper (II) mixed ligand complex; Cytotoxcity; Metallo nucleases; Intercelator; Terpyridine; MOLECULAR RECOGNITION; BINDING; APOPTOSIS; PLATINUM; COOPERATIVITY; NUMBER; DAMAGE; DRUGS;
D O I：
10.1016/j.ejmech.2011.07.030
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two new mixed ligand complexes of copper (II) containing an imidazolyl terpyridine ligand, [Cu(Itpy)(bpy)](ClO4)(2)center dot(H2O), 1, and [Cu(Itpy)(phen) (ClO4)](ClO4)center dot(H2O), 2 have been synthesized and characterized. Complex 1 has been found to possess a distorted square pyramidal geometry whereas 2 exhibit a distorted octahedral geometry. Electronic spectral titrations suggest that 1 and 2 bind to DNA inter-calatively with the binding constant, K-b (4.12 +/- 0.13) x 10(4) M-1 (1) and (6.04 +/- 0.15) x 10(4) M-1 (2). Under physiological condition, in the absence of any external cofactor 2 has been found to bring about DNA cleavage via hydrolytic mechanism but 1 does not bring about any DNA cleavage. Both compounds show antitumor effects on the A549 lung adenocarcinoma cancer cell line. (C) 2011 Elsevier Masson SAS. All rights reserved.
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收藏
页码：4537 / 4547
页数：11
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