Regioselective hydroarylation and arylation of maleimides with indazoles via a Rh(iii)-catalyzed C-H activation

被引：34

作者：

Ghosh, Asim Kumar ^{[1
]}

Samanta, Sadhanendu ^{[1
]}

Ghosh, Payel ^{[1
]}

Neogi, Sukanya ^{[1
]}

Hajra, Alakananda ^{[1
]}

机构：

[1] Visva Rharati Cent Univ, Dept Chem, Santini Ketan 731235, W Bengal, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2020年 / 18卷 / 16期

关键词：

SUBSTITUTED MALEIMIDE; AROMATIC AMIDES; ALKYLATION; ALKENYLATION; BONDS; (HETERO)ARENES; DERIVATIVES; ALDEHYDES; DESIGN; CANCER;

D O I：

10.1039/d0ob00353k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Switchable Rh(iii)-catalyzed highly regioselective hydroarylation and oxidative arylation of maleimides with 2-arylindazoles via C-H activation have been demonstrated. The reaction affords 3-(2-(2H-indazol-2-yl)phenyl)succinimide and 3-(2-(2H-indazol-2-yl)phenyl)maleimide derivatives in high yields with wide functional group tolerance. A mechanistic study was performed to depict C-H bond cleavage that might be involved in the turnover limiting step.

引用

页码：3093 / 3097

页数：5

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