Transition-Metal-Free Coupling Annulation of Arynes with Ketones and Alkynoates: Assembly of Functionalized Naphthalenes

被引：23
|
作者：
Shu, Wen-Ming [1 ,2 ]
Zheng, Kai-Lu [1 ]
Ma, Jun-Rui [1 ]
Wu, An-Xin [1 ]
机构：
[1] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Coll Chem, Wuhan 430079, Hubei, Peoples R China
[2] Yangtze Univ, Coll Chem & Environm Engn, Jingzhou 434023, Peoples R China
来源：
ORGANIC LETTERS | 2016年 / 18卷 / 15期
基金：
中国国家自然科学基金;
关键词：
DIELS-ALDER REACTION; POLYCYCLIC AROMATIC-HYDROCARBONS; REARRANGEMENT AROMATIZATION; SUBSTITUTED NAPHTHALENES; ARYLNAPHTHALENE LIGNAN; ANTIVIRAL ACTIVITY; DERIVATIVES; CHEMISTRY; INSERTION; BENZANNULATION;
D O I：
10.1021/acs.orglett.6b01782
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A transition-metal-free coupling annulation reaction of arynes, ketones, and alkynoates has been demonstrated: Using this formal [2 + 2 + 2] cycloaddition reaction, a wide variety of naphthalene derivatives were conveniently constructed in one pot with high efficiency. In addition, this novel and valid annulation has been successfully applied to the synthesis of 1-phenanthrenol derivatives.
引用
收藏
页码：3762 / 3765
页数：4
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