Investigating the genetic regulation of the expression of 63 lipid metabolism genes in the pig skeletal muscle

被引：6

作者：

Gonzalez-Prendes, R. ^{[1
]}

Quintanilla, R. ^{[2
]}

Amills, M. ^{[1
,3
]}

机构：

[1] CSIC IRTA UAB UB, Ctr Res Agr Genom, Dept Anim Genet, Campus Univ Autonoma Barcelona, Bellaterra 08193, Spain

[2] IRTA, Anim Breeding & Genet Program, Torre Marimon 08140, Caldes De Montb, Spain

[3] Univ Autonoma Barcelona, Fac Vet, Dept Ciencia Anim & Aliments, Bellaterra 08193, Spain

来源：

ANIMAL GENETICS | 2017年 / 48卷 / 05期

关键词：

association analysis; gluteus medius; muscle gene expression; quantitative trait loci; transcriptional regulation; CANDIDATE GENES; COENZYME-A; ASSOCIATION; CHOLESTEROL; POPULATION; NETWORKS; GENOMICS; TRAITS; SET;

D O I：

10.1111/age.12586

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

A comprehensive and systematic view of the genetic regulation of lipid metabolism genes is still lacking in pigs. Herewith, we have investigated the genetic regulation of 63 porcine genes with crucial roles in the uptake, transport, synthesis and catabolism of lipids. With this aim, we have performed an expression QTL (eQTL) scan in 104 pigs with available genotypes for the Illumina Porcine SNP60 chip and microarray measurements of gene expression in the gluteus medius muscle. Analysis of the data with GEMMA software revealed 13 cis- and 18 trans-eQTL modulating the expression of 19 loci. Genes regulated by eQTL participated in a wide array of lipid metabolism pathways such as the beta-oxidation of fatty acids, lipid biosynthesis and lipolysis, fatty acid activation and desaturation, lipoprotein uptake, apolipoprotein assembly and cholesterol trafficking. These data provide a first picture of the genetic regulation of loci involved in porcine lipid metabolism.

引用

页码：606 / 610

页数：5

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